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Antibody responses were rapid after the first vaccine dose. The most commonly encountered adverse reactions were pain at the injection site, fatigue, and headache, but these were transient. These vaccines did not show clear harm in pregnancy. The available data suggested that the mRNA-based vaccines (Pfizer-BioNTech and Moderna) can prevent future SARS-CoV-2 infection. Of those, three studies investigated infection rate, six studies investigated maternal antibody response, seven studies investigated antibody transfer, three studies reported local adverse events, and five studies reported systemic adverse events. There were 13 observational studies with a total of 48,039 pregnant women who received mRNA vaccines. Infection rate, maternal antibody response, transplacental antibody transfer, and adverse events were described. Inclusion criteria were studies that focused on Covid-19 vaccination among pregnant women, while review articles and non-human studies were excluded.
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Manual searches of bioRxiv and medRxiv were also conducted. Registries (, the WHO Clinical Trial Registry, and the European Union Clinical Trial Registry) and databases (MEDLINE, ScienceDirect, Cochrane Library, Proquest, Springer, medRxiv, and bioRxiv) were systematically searched in June 20-22, 2021, for research articles pertaining to Covid-19 and pregnancy. It is important to develop safe vaccines that elicit strong maternal and fetal antibody responses. Pregnancy is a known risk factor for severe Coronavirus disease 2019.